HORDB

ID: hor006440
Uniprot ID: P68004
Protein name: Peptide YY
Gene name: PYY
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Mechanism: NA
Cross BBB: NA
Target: NPY1R
Target Unid: O02813
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 15 minutes; /900 seconds ( PubMed ID: 17065394 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006440_AF2.pdb

hor006440_ESM.pdb

Mass:	457017	Formula:	C176H271N51O55
Absent amino acids:	CFIMW	Common amino acids:	AELRY
pI:	7.52	Basic residues:	6
Polar residues:	10	Hydrophobic residues:	9
Hydrophobicity:	-107.35	Boman Index:	-9946
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	66.18
Instability Index:	8857.94	Extinction Coefficient cystines:	5960
Absorbance 280nm:	180.61